Article
A case example of a radiation-relevant adverse outcome pathway to lung cancer.
International journal of radiation biology - 1 Jan 2021
Chauhan Vinita, Sherman Samantha, Said Zakaria, Yauk Carole L, Stainforth Robert
Abstract excerpt
BACKGROUND: Adverse outcome pathways (AOPs) describe how a measurable sequence of key events, beginning from a molecular initiator, can lead to an adverse outcome of relevance to risk assessment. An AOP is modular by design, comprised of four main components: (1) a Molecular Initiating Event (MIE), (2) Key Events (KEs), (3) Key Event Relationships (KERs) and (4) an Adverse Outcome (AO). PURPOSE: Here, we...
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