Article
Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma.
Scientific reports - 13 Dec 2019
Chakraborty Samarpana, Dakle Pushkar, Sinha Anirban, Vishweswaraiah Sangeetha, Nagori Aditya, Salimath Shivalingaswamy, Prakash Y S, Lodha R, Kabra S K, Ghosh Balaram, Faruq Mohammed, Mahesh P A, Agrawal Anurag
Abstract excerpt
It is estimated from twin studies that heritable factors account for at-least half of asthma-risk, of which genetic variants identified through population studies explain only a small fraction. Multi-generation large families with high asthma prevalence can serve as a model to identify highly penetrant genetic variants in closely related individuals that are missed by population studies. To achieve this, a...
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