Article
Targeted resequencing showing novel common and rare genetic variants increases the risk of asthma in the Chinese Han population.
Journal of clinical laboratory analysis - 1 Jun 2021
Liu Juan, Deng Yanhan, Yu Bo, Mo Biwen, Luo Liman, Yang Jingping, Zhang Xiaoju, Wang Zheng, Wang Yingnan, Zhu Jing, Yang Hua, Fang Shirong, Cheng Zhenshun, Li Jingping, Shu Ying, Luo Guangwei, Xiong Weining, Wei Jianghong, Li Zongzhe
Abstract excerpt
BACKGROUND: Although studies have identified hundreds of genetic variants associated with asthma risk, a large fraction of heritability remains unexplained, especially in Chinese individuals. METHODS: To identify genetic risk factors for asthma in a Han Chinese population, 211 asthma-related genes were first selected based on database searches. The genes were then sequenced for subjects in a Discovery Cohort (284...
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