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Article

Regulating vitamin B12 biosynthesis via the cbiM Cbl riboswitch in Propionibacterium strain UF1

13 Dec 2019

Abstract excerpt

Significance Gut bacteria-associated metabolites pivotally maintain host immune and developmental homeostasis. Here we demonstrate that the cbiM Cbl riboswitch regulates expression of the cobA operon controlling bacterial VB12 biosynthesis. Molecular modification of this riboswitch significantly enhances VB12 production by the commensal Propionibacterium strain UF1. These findings outline the potential to further...

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PMID: 31836694
DOI: 10.1073/pnas.1916576116

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