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Article

Genomes of Leishmania parasites directly sequenced from patients with visceral leishmaniasis in the Indian subcontinent.

PLoS neglected tropical diseases - 1 Dec 2019

Domagalska Malgorzata A, Imamura Hideo, Sanders Mandy, Van den Broeck Frederik, Bhattarai Narayan Raj, Vanaerschot Manu, Maes Ilse, D'Haenens Erika, Rai Keshav, Rijal Suman, Berriman Matthew, Cotton James A, Dujardin Jean-Claude

Abstract excerpt

Whole genome sequencing (WGS) is increasingly used for molecular diagnosis and epidemiology of infectious diseases. Current Leishmania genomic studies rely on DNA extracted from cultured parasites, which might introduce sampling and biological biases into the subsequent analyses. Up to now, direct analysis of Leishmania genome in clinical samples is hampered by high levels of human DNA and large variation in...

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PMID: 31830038
DOI: 10.1371/journal.pntd.0007900
PMCID: PMC6932831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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