Polymorphism in the LASP1 gene promoter region alters cognitive functions of patients with schizophrenia.

doi:10.1038/s41598-019-55414-1

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Article

Polymorphism in the LASP1 gene promoter region alters cognitive functions of patients with schizophrenia.

Scientific reports - 11 Dec 2019

Lin Chieh-Hsin, Yang Sheng, Huang Yu-Jhen, Lane Hsien-Yuan

Abstract excerpt

Schizophrenia's pathogenesis remains elusive. Cognitive dysfunction is the endophenotype and outcome predictor of schizophrenia. The LIM and SH3 domain protein (LASP1) protein, a component of CNS synapses and dendritic spines, has been related to the N-methyl-D-aspartate receptor (NMDAR) dysfunction hypothesis and schizophrenia. A single-nucleotide polymorphism (rs979607) in the LASP1 gene promoter region has...

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PMID: 31827227
DOI: 10.1038/s41598-019-55414-1
PMCID: PMC6906281

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