Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lasp1 is down-regulated in NMDA receptor antagonist-treated mice and implicated in human schizophrenia susceptibility.

Journal of psychiatric research - 1 Jan 2013

Joo Jaesoon, Lee Soojeong, Nah Seong-Su, Kim Young Ock, Kim Duk-Soo, Shim Se-Hoon, Hwangbo Young, Kim Hyung-Kee, Kwon Jun-Tack, Kim Jong Woo, Song Ho-Yeon, Kim Hak-Jae

Abstract excerpt

Mice treated with MK-801, a non-competitive antagonist of the N-methyl-d-aspartic (NMDA) acid receptor, are important animal models for schizophrenia studies. In the present study, we compared protein expression levels in the hippocampus of mice treated with MK-801 (0.6 mg/kg) or saline once daily for 7 days. Changes in the proteome were detected by two-dimensional electrophoresis, and the six proteins exhibiting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoskeletal Proteins
Share to Dizocilpine Maleate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to LIM Domain Proteins

Share to Mice, Inbred ICR

Share to N-Methylaspartate

Share to Random Allocation

Share to Republic of Korea

Source

Identifiers

PMID: 23040864
DOI: 10.1016/j.jpsychires.2012.09.005

Genes

LASP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lasp1 is down-regulated in NMDA receptor antagonist-treated mice and implicated in human schizophrenia susceptibility.PMID 23040864Read ↗

Polymorphism in the LASP1 gene promoter region alters cognitive functions of patients with schizophrenia.Semantic proximity Read ↗

SIPA1L1/SPAR1 is a non-PSD protein involved in GPCR signalingSemantic proximity Read ↗

LIM-Kinases in Synaptic Plasticity, Memory, and Brain DiseasesSemantic proximity Read ↗

Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features.Semantic proximity Read ↗

SULTA4A1 modulates synaptic development and function by promoting the formation of PSD-95/NMDAR complexSemantic proximity Read ↗

Propofol Alters Long Non-Coding RNA Profiles in the Neonatal Mouse Hippocampus: Implication of Novel Mechanisms in Anesthetic-Induced Developmental NeurotoxicitySemantic proximity Read ↗

SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR ComplexSemantic proximity Read ↗

Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia.Semantic proximity Read ↗

Sensitivity to MK-801 in phospholipase C-β1 knockout mice reveals a specific NMDA receptor deficit.Semantic proximity Read ↗

Expression of LIM Protein GenesLmo1, Lmo2,andLmo3in Adult Mouse Hippocampus and Other Forebrain Regions: Differential Regulation by Seizure ActivitySemantic proximity Read ↗

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.Semantic proximity Read ↗

PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.