Article
Free Thyroxine Concentrations in Sera of Individuals with Familial Dysalbuminemic Hyperthyroxinemia: A Comparison of Three Methods of Measurement.
Thyroid : official journal of the American Thyroid Association - 1 Jan 2020
Refetoff Samuel, Scherberg Neal H, Yuan Chao, Wu William, Wu Zengru, McPhaul Michael J
Abstract excerpt
Background: Euthyroid individuals with familial dysalbuminemic hyperthyroxinemia (FDH) have often falsely elevated serum free thyroxine (fT4) concentrations determined by different automated immunoassays. Methods: We measured serum fT4 using direct dialysis coupled with tandem mass spectrometry (fT4 DDMS) in individuals with the common albumin gene mutation (ALB R218H) from 14 FDH families and compared them with...
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