Article
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia.
Thyroid : official journal of the American Thyroid Association - 1 Feb 2004
Hoshikawa Saeko, Mori Kouki, Kaise Nobuko, Nakagawa Yoshinori, Ito Sadayoshi, Yoshida Katsumi
Abstract excerpt
Familial dysalbuminemic hyperthyroxinemia (FDH) is a familial autosomal dominant syndrome caused by abnormal albumin with an increased affinity for thyroxine (T4). Two types of mutations in the albumin gene, replacing the normal arginine 218 with a histidine (R218H) or a proline (R218P), have been reported to cause FDH. Here, we report a pregnant Japanese woman with FDH caused by the mutant albumin R218P. She had...
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