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Article

Familial dysalbuminemic byperthyroxinemia may result in altered warfarin pharmacokinetics.

Chemico-biological interactions - 1 Feb 2000

Petersen C E, Ha C E, Harohalli K, Park D S, Bhagavan N V

Abstract excerpt

Two distinct genotypes that result in the amino acid substitutions R218P and R218H in subdomain 2A of human serum albumin (HSA) have been identified as the cause of familial dysalbuminemic hyperthyroxinemia (FDH). These substitutions increase the affinity of subdomain 2A for thyroxine by approximately 10-fold elevating plasma thyroxine levels in affected individuals. While many studies have examined the binding...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10728776
DOI: 10.1016/s0009-2797(99)00143-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Familial dysalbuminemic byperthyroxinemia may result in altered warfarin pharmacokinetics.PMID 10728776Read ↗

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