Article
A scoring system for the electrostatic complementarities of T-cell receptors and cancer-mutant amino acids: multi-cancer analyses of associated survival rates.
Immunology - 1 Apr 2020
Chobrutskiy Boris I, Yeagley Michelle, Diviney Andrea, Zaman Saif, Gozlan Etienne C, Tipping Price, Koohestani Darush M, Roca Andrea M, Blanck George
Abstract excerpt
The anti-tumor immune response is considered to be due to the T-cell receptor (TCR) binding to tumor antigens, which can be either wild-type, early stem cell proteins, presumably foreign to a developed immune system; or mutant peptides, foreign to the immune system because of a mutant amino acid (aa) or otherwise somatically altered aa sequence. Recently, very large numbers of TCR complementarity-determining...
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