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Article

Bone secreted factors induce cellular quiescence in prostate cancer cells

9 Dec 2019

Abstract excerpt

Disseminated tumor cells (DTCs) undergo a dormant state in the distant metastatic site(s) before becoming overt metastatic diseases. In prostate cancer (PCa), bone metastasis can occur years after prostatectomy, suggesting that bone may provide dormancy-inducing factors. To search for these factors, we prepared conditioned media (CM) from calvariae. Using live-cell imaging, we found that Calvarial-CM treatment...

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PMID: 31819067
DOI: 10.1038/s41598-019-54566-4

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