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Article

Wnt5a induces and maintains prostate cancer cells dormancy in bone

28 Dec 2018

Abstract excerpt

In a substantial fraction of prostate cancer (PCa) patients, bone metastasis appears after years or even decades of latency. Canonical Wnt/β-catenin signaling has been proposed to be implicated in dormancy of cancer cells. However, how these tumor cells are kept dormant and recur under control of Wnt/β-catenin signaling derived from bone microenvironment remains unknown. Here, we report that Wnt5a from...

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PMID: 30593464
DOI: 10.1084/jem.20180661

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