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Article

Interaction between PGRN gene and the early trauma on clinical characteristics in patients with obsessive-compulsive disorder.

Journal of affective disorders - 15 Feb 2020

Wang Pei, Zhao Qing, Xu Tingting, Gu Qiumeng, Liu Qiang, Wang Yong, Lin Guan Ning, Wang Zhen

Abstract excerpt

BACKGROUND: Emerging evidence suggests that obsessive-compulsive disorder (OCD) is caused by a combination of genetic predisposition and environmental factors. In this regard, abnormity of progranulin (PGRN, a key regulator of brain inflammation) and a history of childhood trauma have both been linked to an increased risk of developing OCD. This study is aimed to investigate the association between PGRN and...

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Identifiers

PMID: 31818769
DOI: 10.1016/j.jad.2019.11.111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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