Article
Simultaneous measurement of 25(OH)-vitamin D and 24,25(OH)2-vitamin D to define cut-offs for CYP24A1 mutation and vitamin D deficiency in a population of 1200 young subjects.
Clinical chemistry and laboratory medicine - 28 Jan 2020
Cavalier Etienne, Huyghebaert Loreen, Rousselle Olivier, Bekaert Anne-Catherine, Kovacs Stéphanie, Vranken Laura, Peeters Stéphanie, Le Goff Caroline, Ladang Aurélie
Abstract excerpt
Background Simultaneous measurement of 25(OH)D and 24,25(OH)2D is a new tool for predicting vitamin D deficiency and allows evaluating CYP24A1 lack of function. Interpretation of 24,25(OH)2D should be performed according to 25(OH)D levels and a ratio, called the vitamin D metabolite ratio (VMR) has been proposed for such a purpose. Unfortunately, the VMR can be expressed in different ways and cannot be used if...
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