Article
Genetic variants in the vitamin D pathway and their association with vitamin D metabolite levels: Detailed studies of an inner-city pediatric population suggest a modest but significant effect in early childhood.
The Journal of steroid biochemistry and molecular biology - 1 Oct 2023
Fu Lei, Wong Betty Y L, Li Zhenyu, Horst Ronald L, Williams Rashida, Lee Bonnie, Miller Jessica, Carpenter Thomas O, Cole David E C
Abstract excerpt
OBJECTIVES: In a large cohort of healthy infants and toddlers 6-36 months of age (n = 776), we have been exploring the potential role of genetic variation in predisposition to vitamin D insufficiency. The genes encoding the key cytochrome P450 hydroxylases (CYP2R1, CYP24A1, and CYP27B1) harbour recurrent mutations of uncertain effect. This study was undertaken to look for biochemically relevant associations of...
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