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Article

Binding of HasA by its transmembrane receptor HasR follows a conformational funnel mechanism.

European biophysics journal : EBJ - 1 Jan 2020

Exner Thomas E, Becker Stefanie, Becker Simon, Boniface-Guiraud Audrey, Delepelaire Philippe, Diederichs Kay, Welte Wolfram

Abstract excerpt

HasR in the outer membrane of Serratia marcescens binds secreted, heme-loaded HasA and translocates the heme to the periplasm to satisfy the cell's demand for iron. The previously published crystal structure of the wild-type complex showed HasA in a very specific binding arrangement with HasR, apt to relax the grasp on the heme and assure its directed transfer to the HasR-binding site. Here, we present a new...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31802151
DOI: 10.1007/s00249-019-01411-1
PMCID: PMC6981324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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