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Article

Interactions of HasA, a bacterial haemophore, with haemoglobin and with its outer membrane receptor HasR.

Molecular microbiology - 1 Aug 1999

Létoffé S, Nato F, Goldberg M E, Wandersman C

Abstract excerpt

The major mechanism by which bacteria acquire free or haemoglobin-bound haem involves direct binding of haem to specific outer membrane receptors. Serratia marcescens and Pseudomonas aeruginosa have an alternative system, which involves an extracellular haemophore, HasA, that captures free or haemoglobin-bound haem and shuttles it to a specific cell surface outer membrane receptor, HasR. Both haem-free...

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Identifiers

PMID: 10417645
DOI: 10.1046/j.1365-2958.1999.01499.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interactions of HasA, a bacterial haemophore, with haemoglobin and with its outer membrane receptor HasR.PMID 10417645Read ↗

The heme transfer from the soluble HasA hemophore to its membrane-bound receptor HasR is driven by protein-protein interaction from a high to a lower affinity binding site.Semantic proximity Read ↗

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A new type of hemophore-dependent heme acquisition system of Serratia marcescens reconstituted in Escherichia coli.Semantic proximity Read ↗

Mutagenesis and molecular modeling reveal three key extracellular loops of the membrane receptor HasR that are involved in hemophore HasA binding.Semantic proximity Read ↗

Diverse structural approaches to haem appropriation by pathogenic bacteriaSemantic proximity Read ↗

Binding of HasA by its transmembrane receptor HasR follows a conformational funnel mechanism.Semantic proximity Read ↗

Novel heme ligand displacement by CO in the soluble hemophore HasA and its proximal ligand mutants: implications for heme uptake and release.Semantic proximity Read ↗

The N terminus of the HasA protein and the SecB chaperone cooperate in the efficient targeting and secretion of HasA via the ATP-binding cassette transporter.Semantic proximity Read ↗

The hmuUV genes of Sinorhizobium meliloti 2011 encode the permease and ATPase components of an ABC transport system for the utilization of both haem and the hydroxamate siderophores, ferrichrome and ferrioxamine B.Semantic proximity Read ↗

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