Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models.

doi:10.1016/j.exger.2019.110784

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Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models.

Experimental gerontology - 1 Feb 2020

Zaghini Anna, Sarli Giuseppe, Barboni Catia, Sanapo Mara, Pellegrino Valeria, Diana Alessia, Linta Nikolina, Rambaldi Julie, D'Apice Maria Rosaria, Murdocca Michela, Baleani Massimiliano, Baruffaldi Fabio, Fognani Roberta, Mecca Rosaria, Festa Anna, Papparella Serenella, Paciello Orlando, Prisco Francesco, Capanni Cristina, Loi Manuela, Schena Elisa, Lattanzi Giovanna, Squarzoni Stefano

Abstract excerpt

The transgenic LmnaG609G progeric mouse represents an outstanding animal model for studying the human Hutchinson-Gilford Progeria Syndrome (HGPS) caused by a mutation in the LMNA gene, coding for the nuclear envelope protein Lamin A/C, and, as an important, more general scope, for studying the complex process governing physiological aging in humans. Here we give a comprehensive description of the peculiarities...

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PMID: 31794853
DOI: 10.1016/j.exger.2019.110784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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