Article
Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson-Gilford Progeria Syndrome.
Cells - 24 Apr 2023
Kang So-Mi, Seo Seungwoon, Song Eun Ju, Kweon Okhee, Jo Ah-Hyeon, Park Soyoung, Woo Tae-Gyun, Kim Bae-Hoon, Oh Goo Taeg, Park Bum-Joon
Abstract excerpt
Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare human premature aging disorder that precipitates death because of cardiac disease. Almost all cases of HGPS are caused by aberrant splicing of the LMNA gene that results in the production of a mutant Lamin A protein termed progerin. In our previous study, treatment with Progerinin has been shown to reduce progerin expression and improve aging phenotypes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.