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Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study.

Molecular neurobiology - 1 Mar 2020

Carvalho Carolina Muniz, Wendt Frank R, Stein Dan J, Stein Murray B, Gelernter Joel, Belangero Sintia I, Polimanti Renato

Abstract excerpt

To investigate the causal relationship between blood metabolites and traits related to trauma-response, we combined genome-wide and metabolome-wide datasets generated from large-scale cohorts. Five trauma-response traits ascertained in the UK Biobank (52,816 < N < 117,900 individuals) were considered: (i) "Avoided activities/situations because of previous stressful experience" (Avoidance); (ii) "Felt distant from...

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PMID: 31786776
DOI: 10.1007/s12035-019-01823-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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