Article
Identification of a new GLDC gene alternative splicing variant and its protumorigenic roles in lung cancer.
Future oncology (London, England) - 1 Dec 2019
Yuan Yingli, Sun Luguo, Wang Xu, Chen Jingxian, Jia Mingnan, Zou Yunlong, Sa Huanlan, Cai Yangyang, Xu Yinghui, Sun Chao, Guo Ye, Li Hongwei, Ma Kewei
Abstract excerpt
Aim: To clarify the regulatory roles of GLDCV1, the first identified truncated glycine decarboxylase (GLDC), on cancer stem cells and tumorigenesis. Materials & methods: RT-PCR or RT-qPCR, immunoblotting and immunohistochemical staining were applied to assess gene expression. MTT, BrdU incorporation and colony formation assays were used to examine cell proliferation capacity. Soft agar colony formation and in...
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