Article
Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.
Neuro-oncology - 1 Aug 2011
Miller Suzanne, Rogers Hazel A, Lyon Paul, Rand Vikki, Adamowicz-Brice Martyna, Clifford Steven C, Hayden James T, Dyer Sara, Pfister Stefan, Korshunov Andrey, Brundler Marie-Anne, Lowe James, Coyle Beth, Grundy Richard G
Abstract excerpt
Central nervous system primitive neuroectodermal tumor (CNS PNET) and pineoblastoma are highly malignant embryonal brain tumors with poor prognoses. Current therapies are based on the treatment of pediatric medulloblastoma, even though these tumors are distinct at both the anatomical and molecular level. CNS PNET and pineoblastoma have a worse clinical outcome than medulloblastoma; thus, improved therapies based...
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