Article
Role of proliferative marker index and KBTBD4 mutation in the pathological diagnosis of pineal parenchymal tumors.
Brain tumor pathology - 1 Jul 2022
Uchida Eita, Sasaki Atsushi, Shirahata Mitsuaki, Suzuki Tomonari, Adachi Jun-Ichi, Mishima Kazuhiko, Yasuda Masanori, Fujimaki Takamitsu, Ichimura Koichi, Nishikawa Ryo
Abstract excerpt
Pineal parenchymal tumors (PPTs) are clinically rare and a biopsy is often required for a definitive diagnosis. To improve the accuracy of histological assessment of PPTs, we examined the proliferative capacity of PPT cells and investigated DICER1 expression and KBTBD4 mutations. This study included 19 cases of PPTs [3 pineocytomas (PCs), 10 PPTs of intermediate differentiation (PPTID), and 6 pineoblastomas...
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