Clinical utility of ctDNA by amplicon based next generation sequencing in first line non small cell lung cancer patients.

doi:10.1038/s41598-024-73046-y

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Clinical utility of ctDNA by amplicon based next generation sequencing in first line non small cell lung cancer patients.

Scientific reports - 27 Sept 2024

Gristina Valerio, Russo Tancredi Didier Bazan, Barraco Nadia, Gottardo Andrea, Pepe Francesco, Russo Gianluca, Fulfaro Fabio, Incorvaia Lorena, Badalamenti Giuseppe, Troncone Giancarlo, Malapelle Umberto, Russo Antonio, Bazan Viviana, Galvano Antonio

Abstract excerpt

The assessment of ctDNA has emerged as a minimally invasive avenue for molecular diagnosis and real-time tracking of tumor progression in NSCLC. However, the evaluation of ctDNA by amplicon-based NGS has been not endorsed by all the healthcare systems and remains to be fully integrated into clinical routine practice. To compare tissue single-gene with plasma multiplexed testing, we retrospectively evaluated 120...

Topics

Humans
Carcinoma, Non-Small-Cell Lung
Circulating Tumor DNA
Male
Female
Lung Neoplasms
High-Throughput Nucleotide Sequencing
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Proto-Oncogene Proteins B-raf

Biomarkers, Tumor

Retrospective Studies

Prospective Studies

ErbB Receptors

Adult

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Identifiers

PMID: 39333636
DOI: 10.1038/s41598-024-73046-y
PMCID: PMC11436775

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