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iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy

1 Sept 2020

Abstract excerpt

Recent advances in induced pluripotent stem cell (iPSC) technology and directed differentiation of iPSCs into cardiomyocytes (iPSC-CMs) make it possible to model genetic heart disease in vitro. We apply CRISPR/Cas9 genome editing technology to introduce three RBM20 mutations in iPSCs and differentiate them into iPSC-CMs to establish an in vitro model of RBM20 mutant dilated cardiomyopathy (DCM). In iPSC-CMs...

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PMID: 32905764
DOI: 10.1016/j.celrep.2020.108117

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iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic StrategyPMID 32905764Read ↗

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