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Article

Cell biology of sarcomeric protein engineering: disease modeling and therapeutic potential.

Anatomical record (Hoboken, N.J. : 2007) - 1 Sept 2014

Thompson Brian R, Metzger Joseph M

Abstract excerpt

The cardiac sarcomere is the functional unit for myocyte contraction. Ordered arrays of sarcomeric proteins, held in stoichiometric balance with each other, respond to calcium to coordinate contraction and relaxation of the heart. Altered sarcomeric structure-function underlies the primary basis of disease in multiple acquired and inherited heart disease states. Hypertrophic and restrictive cardiomyopathies are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25125179
DOI: 10.1002/ar.22966
PMCID: PMC4133785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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