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Article

Phenotypic-screening generates active novel fetal globin-inducers that downregulate Bcl11a in a monkey model.

Biochemical pharmacology - 1 Jan 2020

Makino Tomohiro, Haruyama Munetada, Katayama Katsushi, Terashima Hideki, Tsunemi Tomoyuki, Miyazaki Kazuo, Terakawa Maki, Yamashiro Kyoko, Yoshioka Ryosuke, Maeda Hiroaki

Abstract excerpt

Heritable disorders associated with hemoglobin production are the most common monogenic disorders. These are mainly represented by disorders such as β-thalassemia and sickle cell disease. Induction of fetal hemoglobin (HbF) has been known to ameliorate the clinical severity of these β hemoglobinopathies. A high throughput phenotypic screening was used in this study to isolate novel compounds that may enhance the...

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Identifiers

PMID: 31751536
DOI: 10.1016/j.bcp.2019.113717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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