Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases.

doi:10.1038/s41408-019-0252-2

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Article

Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases.

Blood cancer journal - 20 Nov 2019

Mundo Lucia, Ambrosio Maria Raffaella, Raimondi Francesco, Del Porro Leonardo, Guazzo Raffaella, Mancini Virginia, Granai Massimo, Jim Rocca Bruno, Lopez Cristina, Bens Susanne, Onyango Noel, Nyagol Joshua, Abinya Nicholas, Navari Mohsen, Ndede Isaac, Patel Kirkita, Paolo Piccaluga Pier, Bob Roshanak, de Santi Maria Margherita, Russell Robert B, Lazzi Stefano, Siebert Reiner, Stein Harald, Leoncini Lorenzo

Abstract excerpt

MYC is the most altered oncogene in human cancer, and belongs to a large family of genes, including MYCN and MYCL. Recently, while assessing the degree of correlation between MYC gene rearrangement and MYC protein expression in aggressive B-cell lymphomas, we observed few Burkitt lymphoma (BL) cases lacking MYC protein expression despite the translocation involving the MYC gene. Therefore, in the present study we...

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Identifiers

PMID: 31748534
DOI: 10.1038/s41408-019-0252-2
PMCID: PMC6868231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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