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Article

Estimating network changes from lifespan measurements using a parsimonious gene network model of cellular aging.

BMC bioinformatics - 20 Nov 2019

Qin Hong

Abstract excerpt

BACKGROUND: Cellular aging is best studied in the budding yeast Saccharomyces cerevisiae. As an example of a pleiotropic trait, yeast lifespan is influenced by hundreds of interconnected genes. However, no quantitative methods are currently available to infer system-level changes in gene networks during cellular aging. RESULTS: We propose a parsimonious mathematical model of cellular aging based on stochastic...

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Identifiers

PMID: 31747877
DOI: 10.1186/s12859-019-3177-7
PMCID: PMC6865033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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