Distinct molecular profile of IRF4-rearranged large B-cell lymphoma.

doi:10.1182/blood.2019002699

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Article

Distinct molecular profile of IRF4-rearranged large B-cell lymphoma.

Blood - 23 Jan 2020

Ramis-Zaldivar Joan Enric, Gonzalez-Farré Blanca, Balagué Olga, Celis Verónica, Nadeu Ferran, Salmerón-Villalobos Julia, Andrés Mara, Martin-Guerrero Idoia, Garrido-Pontnou Marta, Gaafar Ayman, Suñol Mariona, Bárcena Carmen, Garcia-Bragado Federico, Andión Maitane, Azorín Daniel, Astigarraga Itziar, Sagaseta de Ilurdoz Maria, Sábado Constantino, Gallego Soledad, Verdú-Amorós Jaime, Fernandez-Delgado Rafael, Perez Vanesa, Tapia Gustavo, Mozos Anna, Torrent Montserrat, Solano-Páez Palma, Rivas-Delgado Alfredo, Dlouhy Ivan, Clot Guillem, Enjuanes Anna, López-Guillermo Armando, Galera Pallavi, Oberley Matthew J, Maguire Alanna, Ramsower Colleen, Rimsza Lisa M, Quintanilla-Martinez Leticia, Jaffe Elaine S, Campo Elías, Salaverria Itziar

Abstract excerpt

Pediatric large B-cell lymphomas (LBCLs) share morphological and phenotypic features with adult types but have better prognosis. The higher frequency of some subtypes such as LBCL with IRF4 rearrangement (LBCL-IRF4) in children suggests that some age-related biological differences may exist. To characterize the genetic and molecular heterogeneity of these tumors, we studied 31 diffuse LBCLs (DLBCLs), not...

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PMID: 31738823
DOI: 10.1182/blood.2019002699
PMCID: PMC6978155

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