Article
Altered circadian activity rhythms and sleep in mice devoid of prion protein.
Nature - 18 Apr 1996
Tobler I, Gaus S E, Deboer T, Achermann P, Fischer M, Rülicke T, Moser M, Oesch B, McBride P A, Manson J C
Abstract excerpt
There is a wealth of data supporting a central role for the prion protein (PrP) in the neurodegenerative prion diseases of both humans and other species, yet the normal function of PrP, which is expressed at the cell surface of neurons and glial cells, is unknown. It has been speculated that neuropathology may be due to loss of normal function of PrP. Here we show that in mice devoid of PrP there is an alteration...
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