Article

Inhibition of DNA ligase IV affects the DNA damage repair pathway and decreases the sensitivity of olaparib to platinum-sensitive BRCA wild-type ovarian cancer

2024-09-08

Abstract excerpt

<title>Abstract</title> <p>Ovarian cancer is one of the most common gynecologic malignancies, and the mortality rate has always been the highest among gynecologic malignancies. Currently, the initial treatment mode after the first diagnosis of ovarian cancer is tumor cytoreductive surgery, platinum-based chemotherapy, and targeted drug maintenance therapy. Although PARP inhibitors are an important approach to mai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1467a29-819a-5c4b-a70d-be9dc8cca885
DOI: 10.21203/rs.3.rs-4842625/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of DNA ligase IV affects the DNA damage repair pathway and decreases the sensitivity of olaparib to platinum-sensitive BRCA wild-type ovarian cancerDOI 10.21203/rs.3.rs-4842625/v1Read

Ovarian cancer and DNA repair: DNA ligase IV as a potential keySemantic proximity Read

Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancersSemantic proximity Read

Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeuticsSemantic proximity Read

Establishment and validation of a DNA damage repair gene based model for ovarian cancer typing and prognosisSemantic proximity Read

Targeting DNA Damage Repair and Immune Checkpoint Proteins for Optimizing the Treatment of Endometrial CancerSemantic proximity Read

DNA damaging agents in ovarian cancerSemantic proximity Read

Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer TherapySemantic proximity Read

Olaparib combined with CDK12-IN-3 to promote genomic instability and cell death in ovarian cancerSemantic proximity Read

Case report: Response with chemotherapy and Olaparib in a patient with advanced cervical adenocarcinomaSemantic proximity Read

ALDH1A1 Contributes to PARP Inhibitor Resistance via Enhancing DNA Repair in BRCA2−/− Ovarian Cancer CellsSemantic proximity Read

SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cellsSemantic proximity Read

PARP1 regulates RECQL4 recruitment for DNA double-strand break repairSemantic proximity Read