Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.

doi:10.1021/acs.jmedchem.9b01229

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Article

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.

Journal of medicinal chemistry - 26 Dec 2019

Lin Wen-Hsing, Wu Su-Ying, Yeh Teng-Kuang, Chen Chiung-Tong, Song Jen-Shin, Shiao Hui-Yi, Kuo Ching-Chuan, Hsu Tsu, Lu Cheng-Tai, Wang Pei-Chen, Wu Tsung-Sheng, Peng Yi-Hui, Lin Hui-You, Chen Ching-Ping, Weng Ya-Ling, Kung Fang-Chun, Wu Mine-Hsine, Su Yu-Chieh, Huang Kuo-Wei, Chou Ling-Hui, Hsueh Ching-Cheng, Yen Kuei-Jung, Kuo Po-Chu, Huang Chen-Lung, Chen Li-Tzong, Shih Chuan, Tsai Hui-Jen, Jiaang Weir-Torn

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in acute myeloid leukemia (AML) patients, and these mutations are associated with poor prognosis. In this study, we discovered a multitargeted tyrosine kinase inhibitor, compound 15a, with potent inhibition against...

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PMID: 31721578
DOI: 10.1021/acs.jmedchem.9b01229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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