Article
Screening of triploid with low-coverage whole-genome sequencing by a single-nucleotide polymorphism-based test in miscarriage tissue.
Journal of assisted reproduction and genetics - 1 Dec 2019
Geng Qian, Cui Xiaoli, Zhang Yaqi, Zhang Lijuan, Zhang Cai, Wang Kai, Chen Jianguo, Zhu Qingyan, Xie Jiansheng, Xu Zhiyong, Liu Yang, Zhang MengMeng, Ding Lijie, Zhang Wenyong, Yang Chuanchun
Abstract excerpt
PURPOSE: To establish a single-nucleotide polymorphism-based analysis (SBA) method to identify triploidy in the miscarriage tissue by using low-coverage whole-genome sequencing (LC-WGS). METHODS: The method was established by fitting a quadratic curve model by counting the distribution of three heterozygous mutation content intervals. The triploid test result was mainly determined by the opening direction and the...
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