Article
Comparative study of single-nucleotide polymorphism array and next generation sequencing based strategies on triploid identification in preimplantation genetic diagnosis and screen.
Oncotarget - 6 Dec 2016
Xu Jiawei, Niu Wenbin, Peng Zhaofeng, Bao Xiao, Zhang Meixiang, Wang Linlin, Du Linqing, Zhang Nan, Sun Yingpu
Abstract excerpt
Triploidy occurred about 2-3% in human pregnancies and contributed to approximately 15% of chromosomally caused human early miscarriage. It is essential for preimplantation genetic diagnosis and screen to distinct triploidy sensitively. Here, we performed comparative investigations between MALBAC-NGS and MDA-SNP array sensitivity on triploidy detection. Self-correction and reference-correction algorism were used...
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