Article
Definitive demonstration by synthesis of genome annotation completeness.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2019
Jaschke Paul R, Dotson Gabrielle A, Hung Kay S, Liu Diane, Endy Drew
Abstract excerpt
We develop a method for completing the genetics of natural living systems by which the absence of expected future discoveries can be established. We demonstrate the method using bacteriophage øX174, the first DNA genome to be sequenced. Like many well-studied natural organisms, closely related genome sequences are available-23 Bullavirinae genomes related to øX174. Using bioinformatic tools, we first identified...
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