Article
Obtaining an Ent35-MccV derivative with mutated hinge region that exhibits increased activity against Listeria monocytogenes and Escherichia coli.
Applied microbiology and biotechnology - 1 Dec 2019
Navarro S A, Lanza L, Colombo N S Ríos, de Ullivarri M Fernandez, Acuña L, Sosa-Padilla B, Picariello G, Bellomio A, Chalón Miriam C
Abstract excerpt
The present paper describes the generation of derivatives from the hybrid peptide called Ent35-MccV, active against Gram-positive and Gram-negative bacteria. This peptide has a triple glycine hinge region between enterocin CRL35 and microcin V. In order to obtain variants of Ent35-MccV with greater biotechnological potential, a saturation mutagenesis was carried out in the hinge region. As a result, we obtained a...
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