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Article

Goodpasture disease. Characterization of a single conformational epitope as the target of pathogenic autoantibodies.

The Journal of biological chemistry - 3 Sept 1999

Hellmark T, Burkhardt H, Wieslander J

Abstract excerpt

Goodpasture disease is a prototype autoimmune disease characterized by the formation of autoantibodies against the heterotrimeric basement membrane collagen type IV, which causes a rapidly progressive glomerulonephritis. The pathogenic antibody response is directed to the non-collagenous (NC1) domain of the alpha3 chain of type IV collagen (alpha3(IV)NC1), but not to the homologous region of the alpha1(IV)NC1. To...

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Source

Identifiers

PMID: 10464328
DOI: 10.1074/jbc.274.36.25862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Goodpasture disease. Characterization of a single conformational epitope as the target of pathogenic autoantibodies.PMID 10464328Read ↗

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The Goodpasture AutoantigenSemantic proximity Read ↗

Quaternary Organization of the Goodpasture Autoantigen, the α3(IV) Collagen ChainSemantic proximity Read ↗

Zebrafish to humans: evolution of the 3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndromeSemantic proximity Read ↗

Goodpasture Autoantibodies Unmask Cryptic Epitopes by Selectively Dissociating Autoantigen Complexes Lacking Structural ReinforcementSemantic proximity Read ↗

A Role for Collagen IV Cross-links in Conferring Immune Privilege to the Goodpasture AutoantigenSemantic proximity Read ↗

Update on antiglomerular basement membrane disease.Semantic proximity Read ↗

Alport Alloantibodies but Not Goodpasture Autoantibodies Induce Murine Glomerulonephritis: Protection by Quinary Crosslinks Locking Cryptic α3(IV) Collagen Autoepitopes In VivoSemantic proximity Read ↗

Goodpasture's autoimmune disease — A collagen IV disorderSemantic proximity Read ↗

Distinct Epitopes for Anti–Glomerular Basement Membrane Alport Alloantibodies and Goodpasture Autoantibodies within the Noncollagenous Domain of α3(IV) CollagenSemantic proximity Read ↗

Patients with Goodpasture's disease have two normal COL4A3 alleles encoding the NC1 domain of the type IV collagen alpha 3 chain.Semantic proximity Read ↗

Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice.Semantic proximity Read ↗

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