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Article

Mutational analysis of conserved amino acids in the influenza A virus nucleoprotein.

Journal of virology - 1 May 2009

Li Zejun, Watanabe Tokiko, Hatta Masato, Watanabe Shinji, Nanbo Asuka, Ozawa Makoto, Kakugawa Satoshi, Shimojima Masayuki, Yamada Shinya, Neumann Gabriele, Kawaoka Yoshihiro

Abstract excerpt

The nucleoprotein (NP), which has multiple functions during the virus life cycle, possesses regions that are highly conserved among influenza A, B, and C viruses. To better understand the roles of highly conserved NP amino acids in viral replication, we conducted a comprehensive mutational analysis. Using reverse genetics, we attempted to generate 74 viruses possessing mutations at conserved amino acids of NP. Of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19225007
DOI: 10.1128/JVI.02642-08
PMCID: PMC2668439

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