Article
Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants infected congenitally or postnatally.
Scientific reports - 8 Nov 2019
Paradowska Edyta, Jabłońska Agnieszka, Studzińska Mirosława, Kasztelewicz Beata, Wiśniewska-Ligier Małgorzata, Dzierżanowska-Fangrat Katarzyna, Woźniakowska-Gęsicka Teresa, Czech-Kowalska Justyna
Abstract excerpt
Human cytomegalovirus (CMV) is a major cause of morbidity in fetuses following intrauterine infection. The glycoprotein (g) envelope trimeric gH/gL/gO and pentameric gH/gL/pUL128/pUL130/pUL131A complexes are required for CMV entry into fibroblasts and endothelial/epithelial cells, respectively, and both are targets for neutralizing antibodies. The role of sequence variability among viral strains in the outcome of...
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