Article
Combined genetic variants of human cytomegalovirus envelope glycoproteins as congenital infection markers.
Virology journal - 26 Nov 2015
Arcangeletti Maria-Cristina, Vasile Simone Rosita, Rodighiero Isabella, De Conto Flora, Medici Maria-Cristina, Martorana Davide, Chezzi Carlo, Calderaro Adriana
Abstract excerpt
BACKGROUND: Human cytomegalovirus (HCMV) is still considered to be the main viral cause of birth defects and long-term neurological and sensory sequelae following congenital infection. Several Authors sustain a key role of HCMV envelope glycoproteins, such as gB, gN and gO - mainly involved in cell targeting, viral penetration and spread - as putative virulence factors. The genes coding for these glycoproteins...
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