Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential Inhibition of Human and Trypanosome Ubiquitin E1S by TAK-243 Offers Possibilities for Parasite Selective Inhibitors.

Scientific reports - 7 Nov 2019

Boer D Roeland, Bijlmakers Marie-José

Abstract excerpt

Novel strategies to target Trypanosoma brucei, Trypanosoma cruzi and Leishmania are urgently needed to generate better and safer drugs against Human African Trypanosomiasis, Chagas disease and Leishmaniasis, respectively. Here, we investigated the feasibility of selectively targeting in trypanosomatids the ubiquitin E1 activating enzyme (UBA1), an essential eukaryotic protein required for protein ubiquitination....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Inhibitors
Share to Mutation
Share to Protozoan Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Trypanosoma brucei brucei

Share to Ubiquitin

Share to Ubiquitin-Activating Enzymes

Source

Open in PubMed Open full text

Identifiers

PMID: 31700050
DOI: 10.1038/s41598-019-52618-3
PMCID: PMC6838199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential Inhibition of Human and Trypanosome Ubiquitin E1S by TAK-243 Offers Possibilities for Parasite Selective Inhibitors.PMID 31700050Read ↗

Ubiquitination and the Proteasome as Drug Targets in Trypanosomatid DiseasesSemantic proximity Read ↗

Ubiquitin Proteasome pathway proteins as potential drug targets in parasite Trypanosoma cruziSemantic proximity Read ↗

Repurposing of Human Kinase Inhibitors in Neglected Protozoan DiseasesSemantic proximity Read ↗

Ubiquitin and ubiquitin-like conjugation systems in trypanosomatidsSemantic proximity Read ↗

Drug resistance-associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity.Semantic proximity Read ↗

A novel protein kinase is essential in bloodstream Trypanosoma brucei.Semantic proximity Read ↗

Oligopeptidase B, a missing enzyme in mammals and a potential drug target for trypanosomatid diseasesSemantic proximity Read ↗

Drug resistance-associated mutations in <i>Plasmodium</i> UBP-1 disrupt ubiquitin hydrolysisSemantic proximity Read ↗

Small-molecule inhibition of the <i>Orientia tsutsugamushi</i> deubiquitylating enzyme OtDUB impairs bacterial reproductionSemantic proximity Read ↗

Toxoplasma gondii UBL‐UBA shuttle proteins contribute to the degradation of ubiquitinylated proteins and are important for synchronous cell division and virulenceSemantic proximity Read ↗

An Apicoplast Localized Ubiquitylation System Is Required for the Import of Nuclear-encoded Plastid ProteinsSemantic proximity Read ↗

A Brief Review of Drug Discovery Research for Human African TrypanosomiasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.