Article
Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia.
Nature communications - 7 Nov 2019
Dou Liping, Yan Fei, Pang Jiuxia, Zheng Dehua, Li Dandan, Gao Li, Wang Lijun, Xu Yihan, Shi Jinlong, Wang Qian, Zhou Lei, Shen Na, Singh Puja, Wang Lili, Li Yonghui, Gao Yvchi, Liu Tao, Chen Chongjian, Al-Kali Aref, Litzow Mark R, Chi Young-In, Bode Ann M, Liu Chunhui, Huang Haojie, Liu Daihong, Marcucci Guido, Liu Shujun, Yu Li
Abstract excerpt
The oncogenic fusion protein AML1-ETO retains the ability of AML1 to interact with the enhancer core DNA sequences, but blocks AML1-dependent transcription. Previous studies have shown that post-translational modification of AML1-ETO may play a role in its regulation. Here we report that AML1-ETO-positive patients, with high histone lysine methyltransferase Enhancer of zeste homolog 1 (EZH1) expression, show a...
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