Article
Genetic modifiers of cystic fibrosis-related diabetes.
Diabetes - 1 Oct 2013
Blackman Scott M, Commander Clayton W, Watson Christopher, Arcara Kristin M, Strug Lisa J, Stonebraker Jaclyn R, Wright Fred A, Rommens Johanna M, Sun Lei, Pace Rhonda G, Norris Sarah A, Durie Peter R, Drumm Mitchell L, Knowles Michael R, Cutting Garry R
Abstract excerpt
Diabetes is a common age-dependent complication of cystic fibrosis (CF) that is strongly influenced by modifier genes. We conducted a genome-wide association study in 3,059 individuals with CF (644 with CF-related diabetes [CFRD]) and identified single nucleotide polymorphisms (SNPs) within and 5' to the SLC26A9 gene that associated with CFRD (hazard ratio [HR] 1.38; P = 3.6 × 10(-8)). Replication was...
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