Connexin-caused genetic diseases and corresponding mouse models.

doi:10.1089/ars.2008.2128

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Article

Connexin-caused genetic diseases and corresponding mouse models.

Antioxidants & redox signaling - 1 Feb 2009

Dobrowolski Radoslaw, Willecke Klaus

Abstract excerpt

The human and mouse genomes contain 21 and 20 connexin genes, respectively. During the last 10-year period, genetic research on connexins has been stimulated by two parallel approaches: first, the characterization of genetic diseases that are caused by connexin mutations and, second, the generation and characterization of connexin knockout (null) mutated mice in which the coding region of nearly all connexin...

Topics

Animals
Connexins
Disease Models, Animal
Gap Junctions
Genetic Diseases, Inborn
Humans
Mice
Models, Biological
Mutation
Point Mutation
Protein Isoforms

Source

Open in PubMed

Identifiers

PMID: 18831677
DOI: 10.1089/ars.2008.2128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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