Mutational and Immunophenotypic Profiling of a Series of 8 Tubo-ovarian Carcinosarcomas Revealed a Monoclonal Origin of the Disease.

doi:10.1097/PGP.0000000000000645

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Article

Mutational and Immunophenotypic Profiling of a Series of 8 Tubo-ovarian Carcinosarcomas Revealed a Monoclonal Origin of the Disease.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Jul 2020

Trento Mariangela, Munari Giada, Carraro Valentina, Lanza Cristiano, Salmaso Roberta, Pizzi Sara, Santoro Luisa, Chiarelli Silvia, Dal Santo Luca, Nardelli Giovanni B, Saccardi Carlo, Nicoletto Ornella, Baldoni Alessandra, Rugge Massimo, Fassan Matteo

Abstract excerpt

Carcinosarcomas are rare, highly aggressive neoplasms composed of a combination of carcinomatous and sarcomatous elements. These tumors represent a paradigmatic field for the study of intratumor heterogeneity. A series of 8 tubo-ovarian carcinosarcomas was characterized for the following: (i) immunohistochemical expression of MNF116, epithelial membrane antigen, vimentin, S100, chromogranin, synaptophysin,...

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PMID: 31688243
DOI: 10.1097/PGP.0000000000000645

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