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Article

Ovarian Sertoli-Leydig cell tumors with heterologous rhabdomyosarcoma: Clinicopathologic features and molecular analysis highlighting recurrent genetic alterations.

Histopathology - 1 Apr 2026

Zou Ying S, Mohammed Sanobar Yasmeen, Zhu Jing, Dashti Nooshin K, Smith Colton, Sun Ying, Vang Russell, McCluggage W Glenn, Xing Deyin

Abstract excerpt

AIMS: Ovarian Sertoli-Leydig cell tumor (SLCT) with heterologous rhabdomyosarcoma (RMS) is exceptionally rare. While the presence of heterologous elements in SLCT is highly predictive of an underlying DICER1 mutation, the molecular alterations in these tumors, including in SLCTs with heterologous RMS, remain largely unknown. In this study, we aimed to characterize the clinicopathologic features of these rare...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41395670
DOI: 10.1111/his.70058

Genes

DICER1
TERT
TP53
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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