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Article

Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis

5 Nov 2019

Abstract excerpt

Accumulation of senescent cells is associated with the progression of pulmonary fibrosis, but mechanisms accounting for this linkage are not well understood. To explore this issue, we investigated whether a class of biologically active profibrotic lipids, the leukotrienes (LT), is part of the senescence-associated secretory phenotype. The analysis of conditioned medium (CM), lipid extracts, and gene expression of...

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Share to Chronic Obstructive Pulmonary Disease (COPD) Research
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PMID: 31687975
DOI: 10.1172/jci.insight.130056

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