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Article

ROCK2 promotes osteosarcoma growth and metastasis by modifying PFKFB3 ubiquitination and degradation

1 Nov 2019

Abstract excerpt

Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) are widely involved in cell biological activities and play a key role in controlling various cell phenomena. However, the underlying mechanisms connecting ROCK2 and PFKFB3 in osteosarcoma growth and metastasis are poorly understood. In this study, we explored and analysed the role and...

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PMID: 31678169
DOI: 10.1016/j.yexcr.2019.111689

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